Technology Process of (2R,3S,4R,5R)-5-(diallylamino)-7-phenylhept-6-yne-1,2,3,4-tetraol
There total 1 articles about (2R,3S,4R,5R)-5-(diallylamino)-7-phenylhept-6-yne-1,2,3,4-tetraol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boric acid; isopropyl alcohol; tris(pentafluorophenyl)phosphine; copper(I) bromide;
In
1,4-dioxane;
at 20 ℃;
for 72h;
Reagent/catalyst;
Overall yield = 84 %; Overall yield = 77.9 mg;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/ol401810b
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium diacetate; triphenylphosphine; 1,3-dimethylbarbituric acid / ethanol / 3 h
2: triethylamine / tetrahydrofuran / 5 h / 4 - 20 °C
3: 2,4,6-trimethyl-pyridine / dichloromethane / 15 h / 4 °C
4: dichloromethane / 4 h / 4 °C
5: tetra-(n-butyl)ammonium iodide; triethylamine / 1,4-dioxane / 12 h / 50 °C
With
2,4,6-trimethyl-pyridine; 1,3-dimethylbarbituric acid; palladium diacetate; tetra-(n-butyl)ammonium iodide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/ol401810b
- Guidance literature:
-
With
1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine;
In
ethanol;
for 3h;
DOI:10.1021/ol401810b
