{2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester

Base Information

• Chemical Name: {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester
• CAS No.: 1027410-38-3
• Molecular Formula: C₂₃H₂₂ClN₃O₄S
• Molecular Weight: 471.964
• Mol file: 1027410-38-3.mol

Synonyms:

Chemical Property of {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester

There total 5 articles about {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

saccharin sodium salt (128-44-9) → {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester (1027410-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: acetic anhydride / 0.83 h / Heating

4: dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00102a016

Reference yield:

4-(4-chlorophenyl)butyl tosylate (93982-99-1) → {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester (1027410-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: acetic anhydride / 0.83 h / Heating

4: dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00102a016

Reference yield:

2-[4-(4-Chloro-phenyl)-butyl]-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (1025832-92-1) → {2-[4-(4-Chloro-phenyl)-butyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester (1027410-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

2: acetic anhydride / 0.83 h / Heating

3: dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide;

DOI:10.1021/jm00102a016

upstream raw materials:

potassium cyanide

saccharin sodium salt

4-(4-chlorophenyl)butyl tosylate

2-[4-(4-Chloro-phenyl)-butyl]-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

Downstream raw materials:

C₂₂H₂₁ClN₂O₆S