1H-Indole-5-carboximidamide, 2-[2-[6-(aminoiminomethyl)-1H-indol-2-yl]ethyl]-, dihydrochloride

Base Information

• Chemical Name: 1H-Indole-5-carboximidamide, 2-[2-[6-(aminoiminomethyl)-1H-indol-2-yl]ethyl]-, dihydrochloride
• CAS No.: 104292-01-5
• Molecular Formula: C₂₀H₂₀N₆*2ClH
• Molecular Weight: 417.341
• Mol file: 104292-01-5.mol

Synonyms:

Chemical Property of 1H-Indole-5-carboximidamide, 2-[2-[6-(aminoiminomethyl)-1H-indol-2-yl]ethyl]-, dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-5-carboximidamide, 2-[2-[6-(aminoiminomethyl)-1H-indol-2-yl]ethyl]-, dihydrochloride

There total 3 articles about 1H-Indole-5-carboximidamide, 2-[2-[6-(aminoiminomethyl)-1H-indol-2-yl]ethyl]-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-<2-(6-Cyan-2-indolyl)ethyl>indol-5-carbonitril (104291-77-2) → 2-<2-(6-Amidino-2-indolyl)ethyl>-5-indolcarboxamidin-dihydrochlorid (104292-01-5)

Guidance literature:

DOI:10.1002/jlac.198619861210

Reference yield:

2-formyl-1H-indole-6-carbonitrile (104291-63-6) → 2-<2-(6-Amidino-2-indolyl)ethyl>-5-indolcarboxamidin-dihydrochlorid (104292-01-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / Mangandioxid / acetone / 2 h / Ambient temperature

2: 96 percent / 10percent NaOCH₃ / methanol / 1 h

3: 68 percent / Pd / dimethylformamide / Ambient temperature

4: 76 percent

With Mangandioxid; sodium methylate; palladium; In methanol; N,N-dimethyl-formamide; acetone;

Reference yield:

<(6-Cyan-2-indolyl)methyl>triphenylphosphoniumbromid (104291-64-7) → 2-<2-(6-Amidino-2-indolyl)ethyl>-5-indolcarboxamidin-dihydrochlorid (104292-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent

2: 75 percent / H₂ / Pd(OH)2/BaSO₄ / dimethylformamide / 4 h

3: 60 percent

With hydrogen; palladium dihydroxide; barium sulfate; In N,N-dimethyl-formamide;

DOI:10.1002/jlac.198619861210

upstream raw materials:

2-<2-(6-Cyan-2-indolyl)ethyl>indol-5-carbonitril

2-formyl-1H-indole-6-carbonitrile

<(6-Cyan-2-indolyl)methyl>triphenylphosphoniumbromid

Refernces

• 1、 Dann, Otto,Char, Helmut,Fleischmann, Paul,Fricke, Helmut. "Synthesis of Antileukemic Indolylvinyl-1-benzofurans and -benzothiophenes". . p. 438 - 455. Retrieved 2007/10/02.