3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

Base Information

• Chemical Name: 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol
• CAS No.: 1069046-00-9
• Molecular Formula: C₄H₁₁NO₃*C₃₁H₂₇NO₃
• Molecular Weight: 582.697

Synonyms:

Chemical Property of 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

ASB14780 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

There total 7 articles about 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid (1069044-40-1) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol (1069046-00-9)

Guidance literature:

In ethanol; at 60 ℃; Product distribution / selectivity;

Reference yield:

2-(benzotriazol-1-yl)acetophenone (127876-36-2) → 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol (1069046-00-9)

Guidance literature:

Multi-step reaction with 7 steps

1: titanium tetrachloride / dichloromethane / 3 h / 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

3: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C

4: palladium on activated charcoal; hydrogen / ethanol / 20 °C

5: johnphos; potassium phosphate; palladium diacetate / acetic acid butyl ester / 24 h / 110 °C

6: sodium hydroxide / water; tetrahydrofuran; ethanol / 20 °C

7: water; ethanol / 0.17 h / 20 °C

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; titanium tetrachloride; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid butyl ester; water; toluene; 3: |Heck Reaction;

DOI:10.1021/jm500494y

Reference yield:

1-(5-bromo-1H-indol-3-yl)-2-phenylethanone (1069051-39-3) → 3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol (1069046-00-9)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

2: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C

3: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4: johnphos; potassium phosphate; palladium diacetate / acetic acid butyl ester / 24 h / 110 °C

5: sodium hydroxide / water; tetrahydrofuran; ethanol / 20 °C

6: water; ethanol / 0.17 h / 20 °C

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos; In tetrahydrofuran; diethyl ether; ethanol; acetic acid butyl ester; water; toluene; 2: |Heck Reaction;

DOI:10.1021/jm500494y

upstream raw materials:

3-[1-(4-phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol

2-(benzotriazol-1-yl)acetophenone

1-(5-bromo-1H-indol-3-yl)-2-phenylethanone

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