(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester
CAS No.:211369-98-1
Molecular Formula:C₄₅H₇₁N₃O₁₅
Molecular Weight:894.07
Hs Code.:

(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

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Technology Process of (S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

There total 8 articles about (S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 211369-90-3
(S)-6-tert-Butoxycarbonylamino-2-[(R)-3-((R)-3-hydroxy-butyryloxy)-butyrylamino]-hexanoic acid tert-butyl ester

: (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid (R)-2-((R)-2-chlorocarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

: 211369-98-1
(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

Guidance literature:: With pyridine; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1002/hlca.19980810529

Reference yield:

: 2018-66-8
Z-Leu-OH

: 211369-98-1
(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / Ambient temperature

2: 96 percent / trifluoroacetic acid / CH₂Cl₂ / 12 h

3: 2.) DMF / 1.) r.t., CH₂Cl₂, 2 h; 2.) 2 h

4: 60 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; dmap; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/hlca.19980810529

Reference yield:

: 13288-57-8
1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride

: 211369-98-1
(S)-2-[(R)-3-((R)-3-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyloxy)-butyryloxy]-butyryloxy}-butyryloxy)-butyrylamino]-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / Et₃N, 1-hydroxy-1H-benzotriazole, N-<3-(dimethylamino)propyl>-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h / Ambient temperature

2: 98 percent / 10percent Pd/C, H₂, AcOH / methanol / 8 h

3: 60 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; palladium on activated charcoal; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1002/hlca.19980810529