-2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid

Base Information

• Chemical Name: -2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid
• CAS No.: 212832-77-4
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.364
• Mol file: 212832-77-4.mol

Synonyms:

Chemical Property of -2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of -2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid

There total 1 articles about -2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) + (S)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid (75266-42-1) → -2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid (212832-77-4)

Guidance literature:

With palladium diacetate; tetrabutyl-ammonium chloride; sodium hydrogencarbonate; at 45 ℃; for 24h;

DOI:10.1248/cpb.46.1094

Reference yield:

-2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid (212832-77-4) → (S)-α-<(methoxycarbonyl)amino>-3-methoxybenzenebutanoic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: hexane; methanol; benzene

2: H₂, 0.1 N aq. HCl / 10 percent Pd/C / methanol

3: aq. NaHCO₃ / dioxane / 5 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; hexane; benzene;

DOI:10.1248/cpb.46.1094

Reference yield:

-2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid (212832-77-4) → (S)-2-Amino-4-(3-methoxy-phenyl)-butyric acid (1260618-62-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; Ambient temperature;

DOI:10.1248/cpb.46.1094

upstream raw materials:

3-methoxy-1-iodobenzene

(S)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Downstream raw materials:

-2-<(benzyloxycarbonyl)amino>-4-(3-methoxyphenyl)-3-butenoic acid methyl ester

(S)-2-Amino-4-(3-methoxy-phenyl)-butyric acid