75266-42-1Relevant academic research and scientific papers
RIP1K INHIBITORS
-
Page/Page column 61-63, (2021/10/11)
Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceut
Syntheses of optically active, protected and unprotected vinylglycines
Itaya,Shimizu,Nakagawa,Morisue
, p. 1927 - 1930 (2007/10/02)
Vinylglycine (2) has been shown to undergo racemization under acidic conditions. Optically pure 2 was obtained from 2 · HCl by enzymatic hydrolysis through N-acetylvinylglycine (5), followed by recrystallization. (S)N-(Methoxycarbonyl)vinylglycine (6) was configurationally so unstable under acidic conditions that 6 could not be obtained from 2 in an optically pure form. On the other hand, configurationally stable (S)-N-(9-phenylfluoren-9-yl)vinylglycine methyl ester (9) was synthesized from (S)-homoserine; 9 was hydrolyzed with sodium hydroxide to afford the carboxylic acid 10 of more than 99% ee.
Palladium-catalyzed heck couplings of L-vinylglycine derivatives with vinyl and aryl halides and triflates
Crisp, Geoffrey T.,Glink, Peter T.
, p. 3541 - 3556 (2007/10/02)
The coupling of aryl and vinyl halides and triflates with L-vinylglycine derivatives under the influence of a palladium catalyst is described. The coupling is regioselective and stereoselective with the absolute configuration of the α-amino acid centre be
Intramolecular Electrophilic Additions to Olefins in Organic Syntheses. Stereoselective Synthesis of 3,4-Substituted β-Lactams by Bromine-Induced Oxidative Cyclization of O-Acyl β,γ-Unsaturated Hydroxamic Acid Derivatives
Rajendra, G.,Miller, Marvin J.
, p. 4471 - 4477 (2007/10/02)
A mild, efficient, and stereoselective preparation of 3,4-disubstituted β-lactams is described.The method involves treatment of O-acyl β,γ-unsaturated hydroxamic acids with bromine in mildly basic aqueous acetonitrile at 0 deg C.The resulting rapid reacti
BENZENESULFONYLCARBONITRILE OXIDE. 5. FACE SELECTIVITY OF CYCLOADDITION TO CHIRAL TERMINAL ALKENES
Wade, Peter A.,Singh, Shankar M.,Pillay, M. Krishna
, p. 601 - 612 (2007/10/02)
The diastereomer ratio for cycloaddition of benzenesulfonylcarbonitrile oxide (BSNO) to a series of (S)-vinylglycine-derived alkenes varied from 30:70 to 66:34 depending on the substituents at the chiral center.Isomer ratios were routinely determined by (
