4-fluorophenyl 2-pyrimidinyl ether

Base Information

• Chemical Name: 4-fluorophenyl 2-pyrimidinyl ether
• CAS No.: 271793-71-6
• Molecular Formula: C₁₀H₇FN₂O
• Molecular Weight: 190.177
• Mol file: 271793-71-6.mol

Synonyms:

Chemical Property of 4-fluorophenyl 2-pyrimidinyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-fluorophenyl 2-pyrimidinyl ether

There total 1 articles about 4-fluorophenyl 2-pyrimidinyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Fluorophenol (371-41-5) + 2-bromopyrimidine (4595-60-2) → 4-fluoro(2-pyrimidinyloxy)benzene (271793-71-6)

Guidance literature:

With copper(l) iodide; iron(III)-acetylacetonate; potassium carbonate; In N,N-dimethyl-formamide; at 135 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201406398

Reference yield:

4-fluoro(2-pyrimidinyloxy)benzene (271793-71-6) → 5-fluorobenzo[d]oxazol-2-amine (1682-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; trifluorormethanesulfonic acid; lithium perchlorate / acetonitrile / 20 °C / Inert atmosphere; Electrolysis

2: piperidine / acetonitrile / 3 h / 70 °C / Inert atmosphere

With piperidine; trifluorormethanesulfonic acid; lithium perchlorate; potassium carbonate; In acetonitrile;

DOI:10.1002/chem.201406398

upstream raw materials:

4-Fluorophenol

2-bromopyrimidine

Downstream raw materials:

5-fluorobenzo[d]oxazol-2-amine

Refernces