(1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine

Base Information

• Chemical Name: (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine
• CAS No.: 110691-52-6
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 110691-52-6.mol

Synonyms:

Chemical Property of (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine

There total 3 articles about (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+)-(R)-(1-phenylethyl)isocyanate + (R)-salsolidine (54193-08-7) → (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine (110691-52-6)

Guidance literature:

at 0 ℃;

Reference yield: 44.0%

(1R)-1-phenylethyl isocyanate (33375-06-3) + (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) (493-48-1,5784-74-7,38520-68-2,54193-08-7) → (1S)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine (110691-51-5) + (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine (110691-52-6)

Guidance literature:

In chloroform; at 0 ℃; for 1h;

DOI:10.1002/hlca.19860690620

Reference yield:

(6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) (493-48-1,5784-74-7,38520-68-2,54193-08-7) → (1R)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine (110691-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) 10percent NaOH / methanol; diethyl ether / 24 h / Ambient temperature

2: 86 percent / 0 °C

With sodium hydroxide; In methanol; diethyl ether;

upstream raw materials:

(1R)-1-phenylethyl isocyanate

(6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline)

(R)-salsolidine