54193-08-7

Upstream product

• 91-63-4 2-methylquinoline 
• 34989-82-7 3-methylbenzo[d]isothiazole-1,1-dioxide 
• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 6268-86-6 dimethoxy-6,7 methyl-1 dihydro-3,4 isoquinoleine chlorhydrate 
• 186581-53-3 diazomethane 
• 525-72-4 (+/-)-salsolinol 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 

Downstream Products

• 490-53-9 (+/-)-carnegine 
• 525-72-4 (+/-)-salsolinol 
• 508236-97-3 5-(3,4-Dimethoxybenzylamino)-8-(6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ylmethyl)-2-(2-furyl)[1,2,4]triazolo[1,5-c]pyrimidine 
• 493-48-1 (S)-salsolidine 
• 879466-29-2 C₂₀H₂₅NO₂ 
• 145160-08-3 α-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-1-methyl-2(1H)-isoquinolineethanol 
• 145160-11-8 2-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3,4-dihydro-6,7-dimethoxy-1(2H)-isoquinoline 
• 30562-54-0 2-<2-(3,4-dimethoxyphenyl)ethyl>-3,4-dihydro-6,7-dimethoxy-1(2H)-isoquinoline 
• 101041-13-8 2-Amino-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisochinolin-hydrochlorid 
• 101041-20-7 6,7-Dimethoxy-1-methyl-2-(4-nitrobenzylidenamino)-1,2,3,4-tetrahydroisochinolin 

Relevant academic research and scientific papers

Vancomycin-iridium (III) interaction: An unexplored route for enantioselective imine reduction

The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines allowing to obtain a valuable 61% e.e. (R) in the asymmetric reduction of quinaldine 2. The catalytic system exhibited a saturation kinetics with a calculated efficiency of Kcat/KM = 0.688 h?1mM?1

A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions

(Equation presented) Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.

Asymmetric synthesis of 1-substituted tetrahydroisoquinolines by nucleophilic addition to hydrazonium ions. Application to the enantioselective syntheses of (+)- and (-)-salsolidines and (-)-cryptostyline II

Nucleophilic addition of carbon nucleophiles and metal hydride reagents to hydrazonium salts modified by optically active 2-substituted pyrrolidine auxiliaries leads to highly enantioselective synthesis of 1-substituted tetrahydroisoquinolines. This methodology was applied to asymmetric synthesis of the title isoquinoline alkaloids.

METABOLISM OF SALSOLINOL BY TISSUE CULTURES OF SOME PAPAVERACEAE

(+/-)-Salsolinol, a substance possibly inducing Parkinsonism and alcoholism, was transformed into the 6- and 7-O-monomethylated salsolinols by various plant tissue cultures of Papaveraceae.Only 6-O-methylsalsolinol was further N-methylated to provide N-methylisosalsoline.Key Word Index - Corydalis ochotensis; C. opliocarpa; Macleaya cordata; Papaveraceae; tissue cultures; metabolism; isoquinoline alkaloid; salsolinol.

2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics

Analgesic 1,2,3,4-tetrahydroisoquinolines of the formula (1) STR1 wherein R1 and R2 respectively are hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms, R3 and R4 respectively are hydrogen or alkyl of 1 to 4 car