1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole

Base Information

• Chemical Name: 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole
• CAS No.: 313483-17-9
• Molecular Formula: C₁₉H₁₉N
• Molecular Weight: 261.367
• Mol file: 313483-17-9.mol

Synonyms:

Chemical Property of 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole

Chemical Property:

Purity/Quality:

1-(3,4-DIMETHYLPHENYL)-2-METHYL-5-PHENYL-1H-PYRROLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole

There total 3 articles about 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-o-xylene (95-64-7) + 1-phenylpentane-1,4-dione (583-05-1) → 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole (313483-17-9)

Guidance literature:

With aminosulfonic acid; In water; at 60 ℃; for 5h;

DOI:10.1016/j.tetlet.2017.12.031

Reference yield:

benzaldehyde (100-52-7) → 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole (313483-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 75 °C

2: aq. phosphate buffer; acetonitrile / 23 °C / pH 7.2

With triethylamine; In aq. phosphate buffer; ethanol; acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1039/d0ra06962k

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 1-(3,4-dimethylphenyl)-2-methyl-5-phenyl-1H-pyrrole (313483-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) bis(trifluoromethanesulfonate); manganese(II) chloride tetrahydrate; tert.-butylhydroperoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene / water / 20 h / 60 °C

2: aminosulfonic acid / water / 5 h / 60 °C

With tert.-butylhydroperoxide; manganese(II) chloride tetrahydrate; aminosulfonic acid; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; 2: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1016/j.tetlet.2017.12.031

upstream raw materials:

4-amino-o-xylene

1-phenylpentane-1,4-dione

styrene

benzaldehyde