N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

• Chemical Name: N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
• CAS No.: 222725-66-8
• Molecular Formula: C₄₄H₄₇N₅O₇Si
• Molecular Weight: 785.972
• Mol file: 222725-66-8.mol

Synonyms:

Chemical Property of N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 1 articles about N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N6-benzoyl adenosine (129681-71-6,81265-93-2) → N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (222725-66-8)

Guidance literature:

With pyridine; chromium(VI) oxide; acetic anhydride; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0960-894X(98)00706-9

Reference yield:

N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (222725-66-8) → N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (222725-68-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; In ethanol; Ambient temperature;

DOI:10.1016/S0960-894X(98)00706-9

Reference yield:

N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (222725-66-8) → N-benzoyl-5’-O-(bis(4-methoxyphenyl)(phenyl)methyl)-2’-O-(tert-butyl(dimethyl)silyl)-3‘-O-((2-cyanoethoxy)(diisopropylamino)phosphino)adenosine

Guidance literature:

Multi-step reaction with 2 steps

1: sodium triacetoxyborohydride / ethanol / Ambient temperature

2: 1-MeIm, DIPEA / CH₂Cl₂ / 2 h / Ambient temperature

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00706-9

upstream raw materials:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

Downstream raw materials:

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide