222725-68-0Relevant articles and documents
Bis 2′-5′-RR-(3′F-A)(3′F-A) cyclic dinucleotide compound and uses thereof
-
, (2021/04/14)
The present invention provides the cyclic dinucleotide compound 2′2′-RR-(3′F-A)(3′F-A) as a highly active immune stimulator that activates DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes), and compositions and uses thereof.
LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF
-
Paragraph 0548; 0553-0554, (2019/07/03)
The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present in
Nuclease resistant hammerhead motif: From '5-ribo' to '3-ribo' model
Matulic-Adamic, Jasenka,Daniher, Andrew T.,Gonzalez, Carolyn,Beigelman, Leonid
, p. 157 - 160 (2007/10/03)
Previously developed '5-ribo' nuclease stabilized hammerhead motif was further refined by systematic incorporation of 1-(β-D-xylofuranosyl) adenine (xA) and 1-(β-D-xylofuranosyl) guanine (xG) in the place of conserved ribopurine residues of the catalytic core. Modified ribozymes substituted with xA at positions A15.1 and A6 demonstrated catalytic activity close to the parent stabilized ribozyme. Analogous guanosine substitutions at positions G5, G8 and G12 substantially lowered catalytic rates.