Technology Process of 2-(2,4-dichlorophenyl)-3,6-diethyl-5-(2-ethylbutyl)-pyrazine
There total 4 articles about 2-(2,4-dichlorophenyl)-3,6-diethyl-5-(2-ethylbutyl)-pyrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-ethyl-1-butene;
With
9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran;
for 12h;
Inert atmosphere;
Reflux;
2-chloro-5-(2,4-dichlorophenyl)-3,6-diethylpyrazine;
With
tetrakis(triphenylphosphine) palladium(0); sodium hydroxide;
In
tetrahydrofuran; water;
at 50 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/jm200365y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
1.2: 4 h / 90 °C
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
2.2: 24 h / 50 °C / Inert atmosphere
With
9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm200365y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 4 h / Inert atmosphere; Heating
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2.2: 4 h / 90 °C
3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
3.2: 24 h / 50 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; water; toluene;
1.1: Suzuki coupling;
DOI:10.1021/jm200365y
