(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

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Chemical Name:(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride
CAS No.:75832-13-2
Molecular Formula:C₄₂H₅₆N₅O₁₃PS*ClH
Molecular Weight:938.433
Hs Code.:

(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

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Chemical Property of (S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

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Technology Process of (S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

There total 9 articles about (S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 75816-52-3
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

: 75832-13-2
(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; for 0.5h;

Reference yield:

: 28252-48-4
Z-Ser-Leu-OBu^t

: 75832-13-2
(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) hydrogen, 2.) 0.4N-hydrogen chloride / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) methanol, -15 deg C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 76 percent / pyridine / 4 h / 0 °C

4: 97 percent / 2N hydrogen bromide / acetic acid / 0.75 h

5: 68 percent / N-methylmorpholine / dimethylformamide / Ambient temperature

6: 56 percent / 0.48N hydrochloric acid / acetic acid / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 3160-59-6
N-Cbz-L-Isoleucine

: 75832-13-2
(S)-2-[(S)-2-{(2S,3S)-2-[(S)-3-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanyl)-2-benzyloxycarbonylamino-propionylamino]-3-methyl-pentanoylamino}-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 76 percent / pyridine / 4 h / 0 °C

4: 97 percent / 2N hydrogen bromide / acetic acid / 0.75 h

5: 68 percent / N-methylmorpholine / dimethylformamide / Ambient temperature

6: 56 percent / 0.48N hydrochloric acid / acetic acid / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; triethylamine; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;