(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

Base Information

Chemical Name:(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid
CAS No.:75816-52-3
Molecular Formula:C₆₁H₇₀N₅O₁₃PS
Molecular Weight:1144.29
Hs Code.:

(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

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Chemical Property of (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

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Technology Process of (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

There total 8 articles about (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 73491-26-6,73491-27-7
N^α-benzyloxycarbonyl N^α'-trityl-D-lanthionine α-p-nitrophenyl α'-methyl diester

: 75816-58-9
Ile-Ser(Dpp)-Leu

: 75816-52-3
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 28252-48-4
Z-Ser-Leu-OBu^t

: 75816-52-3
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hydrogen, 2.) 0.4N-hydrogen chloride / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) methanol, -15 deg C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 76 percent / pyridine / 4 h / 0 °C

4: 97 percent / 2N hydrogen bromide / acetic acid / 0.75 h

5: 68 percent / N-methylmorpholine / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 3160-59-6
N-Cbz-L-Isoleucine

: 75816-52-3
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 76 percent / pyridine / 4 h / 0 °C

4: 97 percent / 2N hydrogen bromide / acetic acid / 0.75 h

5: 68 percent / N-methylmorpholine / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; triethylamine; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;