(1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine

Base Information

• Chemical Name: (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine
• CAS No.: 872089-33-3
• Molecular Formula: C₁₃H₁₇N₅
• Molecular Weight: 243.311
• Mol file: 872089-33-3.mol

Synonyms:

Chemical Property of (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine

There total 4 articles about (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-azabicyclo[4.1.0]heptane (286-18-0) → (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine (872089-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid / H₂O; diethyl ether / 20 °C / pH 5

With tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid; In diethyl ether; water;

DOI:10.1139/v05-113

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine (872089-33-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / acetone; H₂O / 17 h / Heating

2: 70 percent / triphenylphosphine / tetrahydrofuran / Heating

3: 70 percent / tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid / H₂O; diethyl ether / 20 °C / pH 5

With sodium azide; tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; water; acetone; 2: Staudinger reaction;

DOI:10.1139/v05-113

Reference yield:

trans-2-azido-1-cyclohexanol → (1R,2R)-trans-2-(5-phenyltetrazol-2-yl)cyclohexylamine (872089-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / triphenylphosphine / tetrahydrofuran / Heating

2: 70 percent / tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid / H₂O; diethyl ether / 20 °C / pH 5

With tetrabutylammonium tetrafluoroborate; sodium acetate; acetic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; water; 1: Staudinger reaction;

DOI:10.1139/v05-113

upstream raw materials:

7-azabicyclo[4.1.0]heptane

cyclohexane-1,2-epoxide