7-Aza-bicyclo[4.1.0]heptane

Base Information

• Chemical Name: 7-Aza-bicyclo[4.1.0]heptane
• CAS No.: 286-18-0
• Molecular Formula: C6H11N
• Molecular Weight: 97.16
• Hs Code.: 2933990090
• Mol file: 286-18-0.mol

Synonyms:2,3-Tetramethyleneaziridine;1,2-cyclohexaneimine;cyclohexene imine;7-Azabicyclo<4.1.0>heptan;AZA009;7-azabicyclo<4.1.0>heptane;7-Azabicyclo[4.1.0]heptane;

Chemical Property of 7-Aza-bicyclo[4.1.0]heptane

Chemical Property:

• Melting Point: 21°C
• Refractive Index: 1.4440 (estimate)
• Boiling Point: 171.72°C (rough estimate)
• PSA: 21.94000
• Density: 0.9480
• LogP: 1.22960

Purity/Quality:

97% ^*data from raw suppliers

7-Azabicyclo[4.1.0]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Aza-bicyclo[4.1.0]heptane

There total 10 articles about 7-Aza-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-acetyl-2-cyclohexene-1-one oxime (28353-73-3) → 7-azabicyclo[4.1.0]heptane (286-18-0) + (+/-)-trans-2-aminocyclohexanol (931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7) + cis-2-amino-cyclohexanol-(1) (38898-70-3) + cyclohexylamine (108-91-8,157973-60-9)

Guidance literature:

With sodium hydroxide; borane; dihydrogen peroxide; Product distribution; multistep reaction; other cyclic O-acetyl α,β-unsaturated aldo- and ketoximes;

Reference yield:

(4R*,5S*)-2,2,2-Trimethoxy-4,5-tetramethylen-1,3,2λ5-oxazaphospholidin → 7-azabicyclo[4.1.0]heptane (286-18-0) + trimethyl phosphite (512-56-1)

Guidance literature:

With methanol; lithium aluminium tetrahydride; Yield given. Multistep reaction; 1) CH₂Cl₂, 40 deg C, 30 min; 2) Et₂O, 0 deg C, 3 h;

DOI:10.1002/hlca.19830660812

Reference yield:

(Z)-cyclohex-2-en-1-one oxime (2228-75-3) → 7-azabicyclo[4.1.0]heptane (286-18-0) + 3-amino-1-cyclohexene (1541-25-9) + cyclohexylamine (108-91-8,157973-60-9)

Guidance literature:

With aluminium hydride; In tetrahydrofuran; for 1h; Heating;

upstream raw materials:

(+/-)-trans-2-aminocyclohexanol

O-acetyl-2-cyclohexene-1-one oxime

cyclohex-2-enone oxime

(Z)-cyclohex-2-en-1-one oxime

Downstream raw materials:

N-[2-(7-aza-norcaran-7-yl)-cyclohexyl]-benzamide

trans-2-acetamidocyclohexanethiol

(+/-)-N-(trans-2-mercapto-cyclohexyl)-benzamide

7-Benzyl-7-aza-bicyclo[4.1.0]heptane