C₄₂H₆₂N₁₂O₁₀S₂*ClH

Base Information

• Chemical Name: C₄₂H₆₂N₁₂O₁₀S₂*ClH
• CAS No.: 78221-76-8
• Molecular Formula: C₄₂H₆₂N₁₂O₁₀S₂*ClH
• Molecular Weight: 995.622
• Mol file: 78221-76-8.mol

Synonyms:

Chemical Property of C₄₂H₆₂N₁₂O₁₀S₂*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₆₂N₁₂O₁₀S₂*ClH

There total 14 articles about C₄₂H₆₂N₁₂O₁₀S₂*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-(2,4,6-trimethylbenzyl)-L-cysteine (78221-55-3) → C42H62N12O10S2*ClH (78221-76-8)

Guidance literature:

Multi-step reaction with 12 steps

1: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

2: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

3: HBr / acetic acid / 0.5 h / Ambient temperature

4: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

5: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

6: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

7: 4.3 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

8: HBr / acetic acid / 0.5 h / Ambient temperature

9: 3.1 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

10: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

11: 1.6 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

12: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1135/cccc19810286

Reference yield:

2-chloromethyl-1,3,5-trimethylbenzene (1585-16-6) → C42H62N12O10S2*ClH (78221-76-8)

Guidance literature:

Multi-step reaction with 13 steps

1: 1) Na, liquid NH₃ / 1) 15 min; 2) 2 h

2: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

3: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

4: HBr / acetic acid / 0.5 h / Ambient temperature

5: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

6: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

7: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

8: 4.3 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

9: HBr / acetic acid / 0.5 h / Ambient temperature

10: 3.1 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

11: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

12: 1.6 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

13: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; ammonia; hydrogen bromide; sodium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1135/cccc19810286

Reference yield:

benzyloxycarbonyl-L-prolyl-NG-p-toluenesulfonyl-L-arginyl-glycine (39594-92-8) → C42H62N12O10S2*ClH (78221-76-8)

Guidance literature:

Multi-step reaction with 7 steps

1: HBr / acetic acid / 0.12 h / 60 °C

2: 4.3 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

3: HBr / acetic acid / 0.5 h / Ambient temperature

4: 3.1 g / N-ethylpiperidine / dimethylformamide / 24 h / Ambient temperature

5: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

6: 1.6 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

7: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; In diethyl ether; acetic acid; N,N-dimethyl-formamide;

DOI:10.1135/cccc19810286

upstream raw materials:

S-(2,4,6-trimethylbenzyl)-L-cysteine

2-chloromethyl-1,3,5-trimethylbenzene

benzyloxycarbonyl-L-prolyl-N^G-p-toluenesulfonyl-L-arginyl-glycine

benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

Downstream raw materials:

C₅₁H₇₁N₁₃O₁₁S₂*ClH

o-nitrobenzenesulfenyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-N^G-p-toluenesulfonyl-L-arginyl-glycine amide

Refernces