[18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

Base Information

• Chemical Name: [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
• CAS No.: 1446701-47-8
• Molecular Formula: C₂₃H₂₄FN₉O
• Molecular Weight: 460.503
• Mol file: 1446701-47-8.mol

Synonyms:

Chemical Property of [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

There total 6 articles about [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

C23H24BrN9O (1446701-46-7) → [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide (1446701-47-8)

Guidance literature:

With [18F]-tetrabutylammonium fluoride; In dimethyl sulfoxide; at 170 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2013.05.026

Reference yield:

2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (918538-08-6,1026146-54-2) → [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide (1446701-47-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 180 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / 5 - 20 °C

2.2: 24 h

3.1: [18F]KF/K₂₂₂ / Microwave irradiation

With thionyl chloride; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.05.026

Reference yield:

2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine (918538-05-3) → [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide (1446701-47-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 °C

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 180 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / 5 - 20 °C

3.2: 24 h

4.1: [18F]KF/K₂₂₂ / Microwave irradiation

With thionyl chloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.05.026

upstream raw materials:

(S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-2-methylpyrrolidine-2-carboxylic acid

C₂₃H₂₄BrN₉O

2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine

2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine