2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-aMine

Base Information

• Chemical Name: 2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-aMine
• CAS No.: 918538-08-6
• Molecular Formula: C₁₂H₁₁ClN₆
• Molecular Weight: 274.713
• Mol file: 918538-08-6.mol

Synonyms:Pyrrolo[2,1-f][1,2,4]triazin-4-amine, 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-;

Chemical Property of 2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-aMine

Chemical Property:

• PSA: 70.90000
• LogP: 2.79980

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-aMine

There total 6 articles about 2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine (918538-05-3) + 3-amino-5-cyclopropyl-1H-pyrazole (175137-46-9) → 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (918538-08-6,1026146-54-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 5 - 20 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1021/jm900786r

Reference yield: 90.0%

5-cyclopropyl-2H-pyrazol-3-ylamine (175137-46-9) + 2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine (918538-05-3) → 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (918538-08-6,1026146-54-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 20 ℃;

Reference yield: 83.0%

2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine (918538-05-3) + 3-amino-5-cyclopropyl-1H-pyrazole (175137-46-9) → 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine (918538-08-6,1026146-54-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 20 ℃;

upstream raw materials:

2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine

3-amino-5-cyclopropyl-1H-pyrazole

pyrrolo[2,1-f][1,2,4]triazine-2,4(1H, 3H)-dione

1-(ethoxyformamido)-1H-pyrrole-2-carboxamide

Downstream raw materials:

N₂-(5-cyclopropyl-1H-pyrazol-3-yl)-N₄-((1S)-1-(4-fluorophenyl)ethyl)pyrrolo[2,1-f][1,2,4]triazine-2,4-diamine

[18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

(S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-2-methylpyrrolidine-2-carboxylic acid