(2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate

Base Information

• Chemical Name: (2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate
• CAS No.: 1443117-46-1
• Molecular Formula: C₃₃H₃₅NO₆
• Molecular Weight: 541.644
• Mol file: 1443117-46-1.mol

Synonyms:

Chemical Property of (2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate

There total 1 articles about (2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-diazo-3-phenyl-propionic acid ethyl ester (15626-54-7) + (S)-3-cinnamoyl-4-isopropyloxazolidin-2-one (454692-66-1) + benzaldehyde (100-52-7) → (2RS,4RS,5RS)-2,5-diphenyl-4-ethoxycarbonyl-4-benzyl-1,3-dioxolane + (2S,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate (1443117-42-7) + (2R,3S,4S,5R)-ethyl 2-benzyl-3,5-diphenyl-4-[(S)-4-isopropyl-2-oxo-3-oxazolidinylcarbonyl]-3-propyltetrahydrofuran-2-carboxylate (1443117-46-1)

Guidance literature:

With rhodium(II) pivalate; In dichloromethane; at -78 ℃; for 1.16667h; diastereoselective reaction; Molecular sieve;

DOI:10.1021/jo400858u

upstream raw materials:

2-diazo-3-phenyl-propionic acid ethyl ester

(S)-3-cinnamoyl-4-isopropyloxazolidin-2-one

benzaldehyde