2-Amino-3-hydroxy-2-phenylpropanoic acid

Base Information

• Chemical Name: 2-Amino-3-hydroxy-2-phenylpropanoic acid
• CAS No.: 6321-86-4
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• NSC Number: 30859
• Mol file: 6321-86-4.mol

Synonyms:2-amino-3-hydroxy-2-phenylpropanoic acid;51196-55-5;185396-35-4;NSC30859;6321-86-4;SCHEMBL1712450;2-hydroxymethyl-2-phenylglycine;HFSABHOSMLOVOY-UHFFFAOYSA-N;NSC-30859

Chemical Property of 2-Amino-3-hydroxy-2-phenylpropanoic acid

Chemical Property:

• Vapor Pressure: 4.59E-07mmHg at 25°C
• Boiling Point: 398.4°C at 760 mmHg
• Flash Point: 194.8°C
• Density: 1.337g/cm³
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 189

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CO)(C(=O)O)N

Technology Process of 2-Amino-3-hydroxy-2-phenylpropanoic acid

There total 25 articles about 2-Amino-3-hydroxy-2-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S,S)-tert-butanesulfinic acid [2-(tert-butyldiphenylsilyloxy)-1-cyano-1-phenylethyl]amide (851165-04-3) → (R)-α-phenylserine (6321-86-4)

Guidance literature:

(S,S)-tert-butanesulfinic acid [2-(tert-butyldiphenylsilyloxy)-1-cyano-1-phenylethyl]amide; With hydrogenchloride; for 12h; Heating;

With methyloxirane; In ethanol; for 2h; Heating;

DOI:10.1055/s-2004-837308

Reference yield: 91.0%

(-)-N-benzoyl-α-hydroxymethylphenylglycine (185396-31-0) → (S)-α-phenylserine (6321-86-4)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

Reference yield: 60.0%

(2R)-3-hydroxy-2-(N-benzyloxyamino)-2-phenylpropionic acid (188909-53-7) → (R)-α-phenylserine (6321-86-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 48h; Ambient temperature;

DOI:10.1016/S0957-4166(98)00146-3

upstream raw materials:

formaldehyd

N-benzyliden-2-phenylglycine ethyl ester

(+)-N-benzoyl-α-hydroxymethylphenylglycine

(-)-N-benzoyl-α-hydroxymethylphenylglycine