(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

Base Information

Chemical Name:(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one
CAS No.:133814-77-4
Molecular Formula:C₄₀H₅₈O₈
Molecular Weight:666.896
Hs Code.:

(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

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Suppliers and Price of (1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

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Chemical Property of (1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

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Technology Process of (1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

There total 1 articles about (1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114114-23-7
(4R,6R)-6-Benzyloxy-4-methyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

: 90074-16-1
(2R,3R)-2,3-<(R)-(4-methoxybenzylidene)dioxy>-2-methylpentanal

: 133782-39-5
(1R,2R,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

: 133814-77-4
(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

Guidance literature:: With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) THF, hexane, 3 h, -60 deg C 2) THF, 15 min, -78 deg C;
DOI:10.1016/S0040-4020(01)96140-X

Reference yield:

: 133814-77-4
(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

: Benzoic acid (S)-2-((4R,5S,6R)-6-{(1R,3R)-3-[(4S,5S,6R)-6-((1R,2R)-1,2-dihydroxy-1-methyl-butyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-1-hydroxy-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 0.032 g / LiAlH(t-BuO)3 / diethyl ether

2: 86 percent / DMP, (+/-)-10-camphorosulfonic acid / 0.67 h / 20 °C

3: m-CPBA / tetrahydrofuran / 0.5 h / 20 °C

4: 68 percent / 2,2-dithio-bis(4-t-butyl-1-isopropylimidazole), PPh₃ / toluene / 20 h / Heating

5: 95 percent / LiAlH₄ / diethyl ether / 1.5 h / -50 deg C to r.t.

6: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; phthalic acid dimethyl ester; 10-camphorsufonic acid; lithium tri-t-butoxyaluminum hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis(4-tert-butyl-1-iso-propyl-1H-imidazol-2-yl)disulfide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)96140-X

Reference yield:

: 133814-77-4
(1S,2S,4R,6R)-6-Benzyloxy-1-[(2R,4S,5R)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-1-hydroxy-2,4-dimethyl-6-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-heptan-3-one

: 133782-40-8
Benzoic acid (S)-2-[(4R,5S,6R)-6-((1R,3R)-3-{(4S,5S,6R)-6-[(1S,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-1-methyl-butyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-1-hydroxy-1-methyl-butyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 0.032 g / LiAlH(t-BuO)3 / diethyl ether

2: 86 percent / DMP, (+/-)-10-camphorosulfonic acid / 0.67 h / 20 °C

3: m-CPBA / tetrahydrofuran / 0.5 h / 20 °C

4: 68 percent / 2,2-dithio-bis(4-t-butyl-1-isopropylimidazole), PPh₃ / toluene / 20 h / Heating

5: 95 percent / LiAlH₄ / diethyl ether / 1.5 h / -50 deg C to r.t.

6: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

7: EtN₃ / CH₂Cl₂ / 0.25 h / -20 - 20 °C

With pyridine; lithium aluminium tetrahydride; phthalic acid dimethyl ester; 10-camphorsufonic acid; lithium tri-t-butoxyaluminum hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis(4-tert-butyl-1-iso-propyl-1H-imidazol-2-yl)disulfide; ethyl azide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)96140-X