Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Base Information

• Chemical Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
• CAS No.: 2003260-55-5
• Molecular Formula: C₂₅H₂₂N₂O₂
• Molecular Weight: 382.462
• Mol file: 2003260-55-5.mol

Synonyms:

Chemical Property of Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Chemical Property:

• Boiling Point: 646.9±55.0 °C(Predicted)
• PKA: 4.81±0.40(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

NCGC00244536 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

There total 5 articles about Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

C26H24N2O2 → C25H22N2O2 (2003260-55-5)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

C16H16BrNO → C25H22N2O2 (2003260-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 18 h / 125 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 18 h / 125 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; boron tribromide; sodium carbonate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

4-bromo-2-methoxyaniline (59557-91-4) → C25H22N2O2 (2003260-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium 3-nitrobenzenesulfonate; sulfuric acid / water / 3 h / 20 - 80 °C

1.2: 120 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 18 h / 125 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; boron tribromide; sodium carbonate; sodium 3-nitrobenzenesulfonate; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

4-bromo-2-methoxyaniline

m-bromobenzoic acid

3-Phenylpropan-1-amine

Refernces