imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

Base Information

Chemical Name:imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester
CAS No.:736990-97-9
Molecular Formula:C₄₂H₆₀N₄O₁₂
Molecular Weight:812.958
Hs Code.:

imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

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Chemical Property of imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

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Technology Process of imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

There total 4 articles about imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81103-11-9
clarithromycin

: 736990-97-9
imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / DMAP; Et₃N / CH₂Cl₂

2: DBU / tetrahydrofuran; dimethylformamide

3: NH₃; t-BuOK

4: 78 percent / HCl / ethanol / 45 °C

5: tetrahydrofuran; 1,2-dichloro-ethane

With hydrogenchloride; dmap; potassium tert-butylate; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.04.077

Reference yield:

: 93-97-0
benzoic acid anhydride

: 736990-97-9
imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / DMAP; Et₃N / CH₂Cl₂

2: DBU / tetrahydrofuran; dimethylformamide

3: NH₃; t-BuOK

4: 78 percent / HCl / ethanol / 45 °C

5: tetrahydrofuran; 1,2-dichloro-ethane

With hydrogenchloride; dmap; potassium tert-butylate; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.04.077

Reference yield:

: 736990-95-7
C₅₃H₇₆N₂O₁₅

: 736990-97-9
imidazole-1-carboxylic acid 10-(3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-8-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / HCl / ethanol / 45 °C

2: tetrahydrofuran; 1,2-dichloro-ethane

With hydrogenchloride; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2004.04.077