Technology Process of <1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthyl>-<1-(phenylseleno)cyclopentyl>methanone
There total 20 articles about <1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthyl>-<1-(phenylseleno)cyclopentyl>methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 98 percent / Br2 / CHCl3 / 0.75 h / 0 °C
2: 82 percent / LDA / tetrahydrofuran / 4 h / -78 °C
3: 70percent aq. perchloric acid / tetrahydrofuran / 1.25 h
4: 58 percent / Tl(NO3)3*3H2O / methanol; CH2Cl2 / 2 h / 0 °C
5: 1) Br2, 2) gl. acetic acid, Br2 / 1) CHCl3, 60 min. 5 deg C, 2) 4 h, rt
7: 62 percent / DDQ / dioxane / 100 °C
8: 89 percent / ZnCl2, Et3N / 80 °C
9: tetrahydrofuran / 6 h / -78 deg C to rt
With
perchloric acid; bromine; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; thallium(III) nitrate; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 82 percent / LDA / tetrahydrofuran / 4 h / -78 °C
2: 70percent aq. perchloric acid / tetrahydrofuran / 1.25 h
3: 58 percent / Tl(NO3)3*3H2O / methanol; CH2Cl2 / 2 h / 0 °C
4: 1) Br2, 2) gl. acetic acid, Br2 / 1) CHCl3, 60 min. 5 deg C, 2) 4 h, rt
6: 62 percent / DDQ / dioxane / 100 °C
7: 89 percent / ZnCl2, Et3N / 80 °C
8: tetrahydrofuran / 6 h / -78 deg C to rt
With
perchloric acid; bromine; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; thallium(III) nitrate; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 58 percent / Tl(NO3)3*3H2O / methanol; CH2Cl2 / 2 h / 0 °C
2: 1) Br2, 2) gl. acetic acid, Br2 / 1) CHCl3, 60 min. 5 deg C, 2) 4 h, rt
4: 62 percent / DDQ / dioxane / 100 °C
5: 89 percent / ZnCl2, Et3N / 80 °C
6: tetrahydrofuran / 6 h / -78 deg C to rt
With
bromine; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; thallium(III) nitrate; zinc(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;