2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid

Base Information

• Chemical Name: 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid
• CAS No.: 875802-13-4
• Molecular Formula: C₂₂H₂₇N₃O₇
• Molecular Weight: 445.472
• Mol file: 875802-13-4.mol

Synonyms:

Chemical Property of 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid

There total 1 articles about 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-formylphenoxy)-2-methylpropanoic acid (85212-83-5) + 6-methyl-5-nitro-1,3-dipropyl-1H-pyrimidine-2,4-dione (157119-79-4) → 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid (875802-13-4)

Guidance literature:

With piperidine; In 1,4-dioxane; Heating;

DOI:10.1021/jm0506221

Reference yield: 25.0%

2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid (875802-13-4) → 2-[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-2-methyl-propionic acid (480994-30-7)

Guidance literature:

With formic acid; sodium dithionite; Heating;

DOI:10.1021/jm0506221

Reference yield:

2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid (875802-13-4) → 2-[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-2-methyl-N-phenyl-propionamide

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / formic acid; sodium dithionite / Heating

2: 47 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂ / 20 °C

With formic acid; sodium dithionite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/jm0506221

upstream raw materials:

2-(4-formylphenoxy)-2-methylpropanoic acid

6-methyl-5-nitro-1,3-dipropyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

2-[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-2-methyl-propionic acid