Technology Process of tert-Butyl N-(benzyloxycarbonyl)-2(RS)-(formylmethyl)pipecolate
There total 5 articles about tert-Butyl N-(benzyloxycarbonyl)-2(RS)-(formylmethyl)pipecolate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 58 percent / H2SO4 / diethyl ether / 24 h / Ambient temperature
2: 1.) LDA / 1.) THF, hexane, EtPh, -78 deg C, 20 min, 2.) -78 deg C, 20 min
3: 1.) OsO4, H2O, 2.) NaIO4 / 1.) THF, 5 min, 2.) 2.5 h
With
sodium periodate; osmium(VIII) oxide; sulfuric acid; water; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jo00056a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / 2 N NaOH / 1 h / < 5 deg C to room temperature
2: 58 percent / H2SO4 / diethyl ether / 24 h / Ambient temperature
3: 1.) LDA / 1.) THF, hexane, EtPh, -78 deg C, 20 min, 2.) -78 deg C, 20 min
4: 1.) OsO4, H2O, 2.) NaIO4 / 1.) THF, 5 min, 2.) 2.5 h
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; sulfuric acid; water; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jo00056a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / 2 N NaOH / 1 h / < 5 deg C to room temperature
2: 58 percent / H2SO4 / diethyl ether / 24 h / Ambient temperature
3: 1.) LDA / 1.) THF, hexane, EtPh, -78 deg C, 20 min, 2.) -78 deg C, 20 min
4: 1.) OsO4, H2O, 2.) NaIO4 / 1.) THF, 5 min, 2.) 2.5 h
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; sulfuric acid; water; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jo00056a018
