2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

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Chemical Name:2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester
CAS No.:145045-89-2
Molecular Formula:C₃₈H₅₂N₂O₁₀Si
Molecular Weight:724.924
Hs Code.:
Mol file:145045-89-2.mol

2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

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Chemical Property of 2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester Edit

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Technology Process of 2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

There total 2 articles about 2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: 145045-88-1
2-{5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-4,5-dihydro-3H-pyrrol-2-ylsulfanyl}-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

: 145045-89-2,145046-05-5
2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In toluene; for 1h; Heating;
DOI:10.1039/P19920002175

Reference yield:

: 145045-86-9
t-butyl 1,2,3,10-tetrahydro-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1-thioxodipyrrin-9-carboxylate

: 145045-89-2,145046-05-5
2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / DBU / CH₂Cl₂ / 1.08 h

2: 82.5 percent / DBU, Ph₃P / toluene / 1 h / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1039/P19920002175