tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

Base Information

Chemical Name:tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate
CAS No.:145045-91-6
Molecular Formula:C₃₂H₄₀N₂O₈
Molecular Weight:580.678
Hs Code.:

tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

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Chemical Property of tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

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Technology Process of tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

There total 3 articles about tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 145045-89-2,145046-05-5
2-[5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-pyrrolidin-(2Z)-ylidene]-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

: 145045-91-6,145046-06-6
tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 17h;
DOI:10.1039/P19920002175

Reference yield:

: 145045-86-9
t-butyl 1,2,3,10-tetrahydro-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1-thioxodipyrrin-9-carboxylate

: 145045-91-6,145046-06-6
tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / DBU / CH₂Cl₂ / 1.08 h

2: 82.5 percent / DBU, Ph₃P / toluene / 1 h / Heating

3: 35 percent / Bu₄NF / tetrahydrofuran / 17 h / 50 °C

With tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1039/P19920002175

Reference yield:

: 145045-88-1
2-{5-[1-[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-4,4-dimethyl-4,5-dihydro-3H-pyrrol-2-ylsulfanyl}-malonic acid benzyl ester 2-trimethylsilanyl-ethyl ester

: 145045-91-6,145046-06-6
tert-Butyl (4Z)-1-benzyloxycarbonylmethylene-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-tetrahydrodipyrrin-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82.5 percent / DBU, Ph₃P / toluene / 1 h / Heating

2: 35 percent / Bu₄NF / tetrahydrofuran / 17 h / 50 °C

With tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1039/P19920002175