2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid

Base Information

• Chemical Name: 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid
• CAS No.: 1428976-99-1
• Molecular Formula: C₁₆H₉NO₆
• Molecular Weight: 311.251
• Mol file: 1428976-99-1.mol

Synonyms:

Chemical Property of 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid

There total 4 articles about 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(4-(мethoxycarbonyl)benzamido)terephthalic acid → 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid (1428976-99-1)

Guidance literature:

With acetic anhydride; for 2h; Reflux;

DOI:10.1016/j.tet.2013.03.024

Reference yield:

4-Methoxycarbonylbenzoyl chloride (7377-26-6) → 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid (1428976-99-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl acetamide / 1.5 h / 20 °C / Cooling with ice

2: potassium hydroxide; water / methanol / 2 h / 60 °C

3: acetic anhydride / 2 h / Reflux

With water; acetic anhydride; triethylamine; potassium hydroxide; In methanol; N,N-dimethyl acetamide;

DOI:10.1016/j.tet.2013.03.024

Reference yield:

2-(4-(мethoxycarbonyl)benzamido)terephthalic acid (1428976-98-0) → 2-(4-сarboxyphenyl)-4-oxo-4H-benzo[d][1,3]oxazine-7-carboxylic acid (1428976-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; water / methanol / 2 h / 60 °C

2: acetic anhydride / 2 h / Reflux

With water; acetic anhydride; potassium hydroxide; In methanol;

DOI:10.1016/j.tet.2013.03.024

upstream raw materials:

4-Methoxycarbonylbenzoyl chloride

3-aminoterephthalic acid

2-(4-(мethoxycarbonyl)benzamido)terephthalic acid

Downstream raw materials:

C₁₆H₇Cl₂NO₄

7-(2-oxoazepane-1-carbonyl)-2-(4-(2-oxoazepane-1-carbonyl)phenyl)-4H-benzo[d][1,3]oxazin-4-one

7-(2-oxoazepane-1-carbonyl)-2-(4-(2-oxoazepane-1-carbonyl)phenyl)-4H-benzo[d][1,3]oxazin-4-one

7-(2-oxoazepane-1-carbonyl)-2-(4-(2-oxoazepane-1-carbonyl)phenyl)-4H-benzo[d][1,3]oxazin-4-one