3-(4-chlorobenzoyl)-2-methylaminopyridine

Base Information

• Chemical Name: 3-(4-chlorobenzoyl)-2-methylaminopyridine
• CAS No.: 178548-97-5
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.696
• Mol file: 178548-97-5.mol

Synonyms:

Chemical Property of 3-(4-chlorobenzoyl)-2-methylaminopyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorobenzoyl)-2-methylaminopyridine

There total 4 articles about 3-(4-chlorobenzoyl)-2-methylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoropyridine (372-48-5) → 3-(4-chlorobenzoyl)-2-methylaminopyridine (178548-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane / 2.5 h / Cooling with acetone-dry ice; Inert atmosphere

1.2: 20 °C / Cooling with acetone-dry ice; Inert atmosphere

2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: ethanol / 20 °C / Inert atmosphere

With sodium acetate; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane;

DOI:10.1021/jm400704g

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 3-(4-chlorobenzoyl)-2-methylaminopyridine (178548-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane / 2.5 h / Cooling with acetone-dry ice; Inert atmosphere

1.2: 20 °C / Cooling with acetone-dry ice; Inert atmosphere

2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: ethanol / 20 °C / Inert atmosphere

With sodium acetate; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane;

DOI:10.1021/jm400704g

Reference yield:

(4-chlorophenyl)(2-fluoropyridin-3-yl)methanol (944654-20-0) → 3-(4-chlorobenzoyl)-2-methylaminopyridine (178548-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: ethanol / 20 °C / Inert atmosphere

With sodium acetate; pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1021/jm400704g

upstream raw materials:

2-fluoropyridine

(4-chlorophenyl)(2-fluoropyridin-3-yl)methanone

methylamine

4-chlorobenzaldehyde

Downstream raw materials:

N-[3-(4-chlorobenzoyl)-2-pyridyl]-N-methylacetamide