Technology Process of (2S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutansaeure-<(1R,2S,3S,4S)-3-benzyl-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>ester
There total 1 articles about (2S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutansaeure-<(1R,2S,3S,4S)-3-benzyl-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) carbonyldiimidazole / 2) lithium imidazolide / 1) CH2Cl2, 10 min, 2) r.t.
2: tetrahydrofuran / 16 h / -20 °C
With
1,1'-carbonyldiimidazole;
lithium salt of imidazole;
In
tetrahydrofuran;
DOI:10.1002/hlca.19900730431
- Guidance literature:
-
Multi-step reaction with 6 steps
1: reducing agent: hydride
2: 95 percent / pyridine / CH2Cl2 / a) 0 deg C, 1h, b) r.t., 16h
3: 105 mg / 1,5N KOH/EtOH / 0.17 h / Ambient temperature
4: CuBr*Me2S / diethyl ether / Ambient temperature; or Cu(I)-pentin-1-ide
5: 480 mg / Ce(NH4)2(NO3)6 / acetonitrile; H2O / 1 h / Ambient temperature
6: 1) H2, 2) conc. HCl / 1) 10percent Pd/C / 1) MeOH, 760 Torr, 2) 50 deg C, 2h
With
pyridine; hydrogenchloride; potassium hydroxide; ammonium cerium(IV) nitrate; copper(I) bromide dimethylsulfide complex; ethanol; hydrogen;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19900730431
- Guidance literature:
-
Multi-step reaction with 5 steps
1: reducing agent: hydride
2: 95 percent / pyridine / CH2Cl2 / a) 0 deg C, 1h, b) r.t., 16h
3: 105 mg / 1,5N KOH/EtOH / 0.17 h / Ambient temperature
4: CuBr*Me2S / diethyl ether / Ambient temperature; or Cu(I)-pentin-1-ide
5: 480 mg / Ce(NH4)2(NO3)6 / acetonitrile; H2O / 1 h / Ambient temperature
With
pyridine; potassium hydroxide; ammonium cerium(IV) nitrate; copper(I) bromide dimethylsulfide complex; ethanol;
In
diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19900730431
