2--N''-<(R)-α-methylbenzyl>acetamide

Base Information

• Chemical Name: 2--N''-<(R)-α-methylbenzyl>acetamide
• CAS No.: 166903-14-6
• Molecular Formula: C₁₅H₂₂N₂O
• Molecular Weight: 246.352
• Mol file: 166903-14-6.mol

Synonyms:

Chemical Property of 2--N''-<(R)-α-methylbenzyl>acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2--N''-<(R)-α-methylbenzyl>acetamide

There total 4 articles about 2--N''-<(R)-α-methylbenzyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

N-acetyl-1-phenylethylamine (36283-44-0,6284-14-6) + pivalaldehyde (630-19-3) → 2--N''-<(R)-α-methylbenzyl>acetamide (166903-14-6)

Guidance literature:

DOI:10.1016/0040-4020(95)00091-L

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → 2--N''-<(R)-α-methylbenzyl>acetamide (166903-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) oxalyl chloride / 1.) CH₂Cl₂, DMF, room temperature, 2 h, 2.) room temperature, overnight

2: 100 percent / H₂ / Pd/C / methanol / 35 °C / 7600 Torr

3: Et₃N / CH₂Cl₂ / 5 h / Heating

With oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo00125a029

Reference yield:

2--N''-<(R)-α-methylbenzyl>acetamide (170309-33-8) → 2--N''-<(R)-α-methylbenzyl>acetamide (166903-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol / 35 °C / 7600 Torr

2: Et₃N / CH₂Cl₂ / 5 h / Heating

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo00125a029

upstream raw materials:

N-acetyl-1-phenylethylamine

pivalaldehyde

2-Amino-N-((R)-1-phenyl-ethyl)-acetamide

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

(2S,5S,1'R)-1-benzoyl-2-tert-butyl-5-methyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

(2R,5R,1'R)-1-benzoyl-2-tert-butyl-5-methyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

(2S,1'R)-1-benzoyl-2-tert-butyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

(2R,1'R)-1-benzoyl-2-tert-butyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one