(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide
CAS No.:1421236-95-4
Molecular Formula:C₂₄H₃₄N₄O₄S
Molecular Weight:474.624
Hs Code.:

(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Synonyms:

Suppliers and Price of (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421236-70-5
(R,E)-2-methyl-N-((1-methyl-1H-pyrazol-3-yl)methylene)propane-2-sulfinamide

: 168297-93-6
(S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one

: 1421236-95-4
(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

: (R)-N-(3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Overall yield = 38 %; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol3033785

Reference yield:

: 168297-85-6,352438-06-3
(S)-4-benzyl-5,5-dimethyloxazolidin-2-one

: 1421236-95-4
(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

: (R)-N-(3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1021/ol3033785

Reference yield:

: 27258-32-8
1-methyl-1H-pyrazole-3-carbaldehyde

: 1421236-95-4
(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

: (R)-N-(3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloromethane / 20 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

With sodium hexamethyldisilazane; caesium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol3033785