27258-32-8

Basic information

• Product Name: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
• Synonyms: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE;1H-PYRAZOLE-3-CARBOXALDEHYDE, 1-METHYL-;AKOS B007390;3-Formyl-1-methyl-1H-pyrazole;1-Methyl-1H-pyrazol-3-carbaldehyde;1-methyl-1H-Pyrazole-3-carboxaldehyde;1-Methyl-3-pyrazolecarboxaldehyde;1-Methylpyrazole-3-carbaldehyde
• CAS NO: 27258-32-8
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: Building Blocks;Pyrazole
• Mol File: 27258-32-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 218.9±13.0℃ (760 Torr)
• Flash Point: 86.2±19.8℃
• Appearance: /
• Density: 1.14±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.123mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.06±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(27258-32-8)
• EPA Substance Registry System: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE(27258-32-8)

Safety Data

• Hazardous Substances Data: 27258-32-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazole-3-carbaldehyde, also known as 1-Methylpyrazole-3-carboxaldehyde, is a chemical compound that falls under the category of pyrazoles. It is often used in the field of pharmaceutical and chemical research due to its intriguing combination of a heterocyclic core and an aldehyde group. The molecular formula for 1-Methyl-1H-pyrazole-3-carbaldehyde is C5H6N2O, and it has a molecular weight of 110.113g/mol. The compound has several applications, including but not limited to serving as an intermediate in the synthesis of other chemical products, such as pharmaceutical drugs or dyes. Its proper handling and storage require it to be kept in a cool, ventilated, and dry place, away from oxidizing agents, due to its reactive nature.

InChI:InChI=1/C5H6N2O/c1-7-3-2-5(4-8)6-7/h2-4H,1H3

Upstream product

• 3920-50-1 3-formylpyrazole 
• 74-88-4 methyl iodide 
• 67751-23-9 4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one 
• 60-34-4 methylhydrazine 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 
• 84547-60-4 1-methyl-1H-pyrazole-3-carbonyl chloride 
• 25016-20-0 1-methylpyrazole-3-carboxylic acid 

Downstream Products

• 1214997-78-0 4-iodo-1-methyl-1H-pyrazole-3-carbaldehyde 
• 79080-39-0 1-Methylpyrazole-3-carboxylic acid nitrile 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 
• 60031-47-2 1-(1-methyl-1H-pyrazol-3-yl)ethanol 
• 1610371-10-2 3-((2-(4-bromophenyl)hydrazono)methyl)-1-methyl-1H-pyrazole 
• 1610371-83-9 C₃₁H₃₀FN₅O 
• 1610371-16-8 2-(1',4-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)acetonitrile 
• 1610371-15-7 2-(1-(4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)acetonitrile 
• 1610371-14-6 1-((4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)methyl methanesulfonate 
• 1610371-13-5 1-((4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazol]-5-yl)methanol 
• 1610371-12-4 methyl 1-(4-bromophenyl)-1',4-dimethyl-4,5-dihydro-1H,1'H-[3,3'-bipyrazole]-5-carboxylate 
• 1610371-11-3 N-(4-bromophenyl)-1-methyl-1H-pyrazole-3-carbohydrazonoyl bromide 
• 1421236-95-4 (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(1-methyl-1H-pyrazol-3-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide 
• 1355994-27-2 ethyl 1-(4-methoxybenzyl)-3-((1-methyl-1H-pyrazol-3-yl)methylamino)-1H-pyrazole-4-carboxylate 

Relevant articles and documents

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Pyrazolopyridine compound and use thereof

The present invention relates to a pyrazolopyridine compound and use thereof, and further relates to a pharmaceutical composition comprising the pyrazolopyridine compound. The pyrazolopyridine compound or the pharmaceutical composition can be used as a so

Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.