Technology Process of 2-(9-Benzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide
There total 8 articles about 2-(9-Benzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) acetic acid, 3 Angstroem molecular sieves, 2.) NaBH3CN / 1.) ethanol, 1 h, 2.) ethanol, RT, 2 d
2: triethylamine / CH2Cl2
3: conc. sulfuric acid / diethyl ether / 3 h
4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H2O / 0.5 h
6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl chloride, N,N-dimethylformamide / CH2Cl2 / 1 h
2: triethylamine / CH2Cl2
3: conc. sulfuric acid / diethyl ether / 3 h
4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H2O / 0.5 h
6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; oxalyl dichloride; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / CH2Cl2
2: conc. sulfuric acid / diethyl ether / 3 h
3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H2O / 0.5 h
5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a014
