3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Base Information

Chemical Name:3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide
CAS No.:1374454-62-2
Molecular Formula:C₂₈H₂₅ClN₆O₆
Molecular Weight:576.996
Hs Code.:

3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Chemical Property of 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Technology Process of 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

There total 8 articles about 3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4382-54-1
5-methoxy-1H-indole-2-carboxylic acid

: 1374454-62-2
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

1.2: 20 °C / Cooling with ice

2.1: N-chloro-succinimide / acetonitrile / 3 h / Reflux

3.1: trichlorophosphate / 1,4-dioxane / 3 h / Reflux

4.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 3 h / Reflux

5.1: dichloromethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

7.1: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Cooling with ice

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Cooling with ice

With N-chloro-succinimide; oxalyl dichloride; hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1391759-95-7
3-chloro-5-methoxy-1H-indole-2-carboxylic acid amide

: 1374454-62-2
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 1,4-dioxane / 3 h / Reflux

2: hydroxylamine hydrochloride; triethylamine / ethanol; water / 3 h / Reflux

3: dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

5: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Cooling with ice

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Cooling with ice

With hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1374452-55-7
3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indole

: 1374454-62-2
3-methoxy-isoxazole-5-carboxylic acid (1-{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

2: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Cooling with ice

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper diacetate; In dichloromethane; N,N-dimethyl-formamide;