Technology Process of (E,R)-3-isopropyl-3-phenyl-4-hexenoic acid
There total 2 articles about (E,R)-3-isopropyl-3-phenyl-4-hexenoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: propionic acid / 150 °C
2: aq. KOH / ethanol / 6 h / Heating
With
potassium hydroxide; propionic acid;
In
ethanol;
1: Claisen-Johnson rearrangement;
DOI:10.1055/s-2005-861856
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Et3N / tetrahydrofuran / 1 h
2: diethyl ether / 1 h / -15 °C
3: NaBH4 / ethanol / 4 h / 20 °C
4: pyridine / 12 h / 20 °C
5: ozone; PPh3 / CH2Cl2; methanol / -78 °C
6: NH2OH*HCl; NaOAc / ethanol / 24 h / 20 °C
7: Ac2O; NaOAc / 6 h / Heating
8: aq. KOH / ethanol / 4 h / 20 °C
With
pyridine; potassium hydroxide; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; ozone; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2005-861856
