C₃₀H₃₀F₂N₂O₂

Base Information

• Chemical Name: C₃₀H₃₀F₂N₂O₂
• CAS No.: 1417404-31-9
• Molecular Formula: C₃₀H₃₀F₂N₂O₂
• Molecular Weight: 488.577
• Mol file: 1417404-31-9.mol

Synonyms:

Chemical Property of C₃₀H₃₀F₂N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₀F₂N₂O₂

There total 15 articles about C₃₀H₃₀F₂N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H12Cl2O3 → C30H30F2N2O2 (1417404-31-9)

Guidance literature:

Multi-step reaction with 7 steps

1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

2: thionyl chloride / dichloromethane / 1 h / Reflux

3: dichloromethane / 0 - 20 °C

4: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

5: hydrogenchloride; water / 6 h / Reflux

6: thionyl chloride / tetrahydrofuran / 1 h / Reflux

7: dichloromethane / 20 °C

With hydrogenchloride; aluminum (III) chloride; thionyl chloride; potassium tert-butylate; water; palladium diacetate; XPhos; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 1: |Friedel-Crafts Acylation / 4: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm301539x

Reference yield:

C16H10Cl2O2 → C30H30F2N2O2 (1417404-31-9)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 0 - 20 °C

2: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

3: hydrogenchloride; water / 6 h / Reflux

4: thionyl chloride / tetrahydrofuran / 1 h / Reflux

5: dichloromethane / 20 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; water; palladium diacetate; XPhos; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm301539x

Reference yield:

2,4-dicyanotoluene (1943-88-0) → C30H30F2N2O2 (1417404-31-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: water; sodium hydroxide / diethylene glycol / 120 h / Reflux

2.1: sulfuric acid / 6 h / Reflux

3.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 - 0 °C

3.2: -78 - 0 °C

4.1: potassium hydroxide / methanol / 6 h / Reflux

5.1: thionyl chloride / dichloromethane / Reflux

6.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

7.1: thionyl chloride / dichloromethane / 1 h / Reflux

8.1: dichloromethane / 0 - 20 °C

9.1: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

10.1: hydrogenchloride; water / 6 h / Reflux

11.1: thionyl chloride / tetrahydrofuran / 1 h / Reflux

12.1: dichloromethane / 20 °C

With hydrogenchloride; aluminum (III) chloride; n-butyllithium; thionyl chloride; sulfuric acid; potassium tert-butylate; water; palladium diacetate; diisopropylamine; potassium hydroxide; sodium hydroxide; XPhos; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; tert-butyl alcohol; diethylene glycol; 6.1: |Friedel-Crafts Acylation / 9.1: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm301539x

upstream raw materials:

[(1R)-1-cyclohexylethyl]amine

2,4-dicyanotoluene

4-methyl isophthalic acid

dimethyl 4-methylbenzene-1,3-dicarboxylate

Refernces