N-desmethyl loperamide

Base Information

Chemical Name:N-desmethyl loperamide
CAS No.:66164-07-6
Molecular Formula:C28H31 Cl N2 O2
Molecular Weight:463.019
Hs Code.:2933399090
UNII:0R07BFN7L3
DSSTox Substance ID:DTXSID70430956
Nikkaji Number:J1.407.206C
Wikidata:Q27132987
Pharos Ligand ID:U2AMKWQMZLML
Metabolomics Workbench ID:63106
ChEMBL ID:CHEMBL1627

Synonyms:(11C)N-desmethyl-loperamide;(N-methyl-11C)-desmethyl-loperamide;N-demethyl-loperamide;N-demethylloperamide;N-desmethyl-loperamide;N-desmethylloperamide

Suppliers and Price of N-desmethyl loperamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Desmethyl Loperamide
1mg
$ 475.00

TRC
N-DesmethylLoperamide
2mg
$ 365.00

Cayman Chemical
N-Desmethyl-loperamide ≥98%
1mg
$ 293.00

Cayman Chemical
N-Desmethyl-loperamide ≥98%
5mg
$ 876.00

Cayman Chemical
N-Desmethyl-loperamide ≥98%
500μg
$ 163.00

Biosynth Carbosynth
N-Desmethyl loperamide
10 mg
$ 1747.20

Biosynth Carbosynth
N-Desmethyl loperamide
25 mg
$ 3281.50

Biosynth Carbosynth
N-Desmethyl loperamide
5 mg
$ 961.00

Biosynth Carbosynth
N-Desmethyl loperamide
2 mg
$ 528.60

Biosynth Carbosynth
N-Desmethyl loperamide
1 mg
$ 290.70

Total 19 raw suppliers

Chemical Property of N-desmethyl loperamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:219-221oC
Boiling Point:678.336°C at 760 mmHg
PKA:13.85±0.20(Predicted)
Flash Point:364.044°C
PSA：52.57000
Density:1.197g/cm³
LogP:5.07460
Storage Temp.:-20°C Freezer
XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:462.2074059
Heavy Atom Count:33
Complexity:595

Purity/Quality:

99%, ^*data from raw suppliers

N-Desmethyl Loperamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Uses Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-Desmethyl-loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. dLop in biological samples can be analyzed by a variety of methods.

Technology Process of N-desmethyl loperamide

There total 7 articles about N-desmethyl loperamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.2%

: 66164-06-5
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide

: 74-88-4
methyl iodide

: 66164-07-6
Desmethylloperamide

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm800510m

Reference yield:

: 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-methyl-2,2-diphenylbutanamide trifluoroacetate

: 66164-07-6
Desmethylloperamide

Guidance literature:: With ammonia; In water;
DOI:10.1016/j.bmcl.2013.08.024

Reference yield:

: 37743-06-9
N-(tetrahydro-3,3-diphenyl-2-furylidene)methylamine hydrobromide

: 66164-07-6
Desmethylloperamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / pH 12

2: hydrogenchloride / chloroform / 1 h / Reflux

3: potassium iodide; 4-methyl-2-pentanone; sodium carbonate / 80 °C / Dean-Stark; Reflux

4: ammonia / water

With hydrogenchloride; ammonia; sodium carbonate; 4-methyl-2-pentanone; potassium iodide; sodium hydroxide; In chloroform; water;
DOI:10.1016/j.bmcl.2013.08.024