N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

Base Information

Chemical Name:N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide
CAS No.:1346641-99-3
Molecular Formula:C₂₆H₃₂F₄N₂O
Molecular Weight:464.546
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

Chemical Property:

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Technology Process of N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

There total 6 articles about N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1346640-97-8
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-methylcyclopropanecarboxamide

: C₇H₁₃BF₃^(1-)*K⁽¹⁺⁾

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

: 1346641-99-3
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

Guidance literature:: With palladium diacetate; lithium carbonate; silver carbonate; p-benzoquinone; In tetrahydrofuran; N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja207607s

Reference yield:

: 1346641-14-2
C₉H₁₆O₂

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

: 1346641-99-3
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / 1,4-dioxane / 20 °C

2: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: toluene / 12 h / Reflux

4: palladium diacetate; lithium carbonate; silver carbonate; p-benzoquinone / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; water; palladium diacetate; lithium carbonate; silver carbonate; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja207607s

Reference yield:

: 773-82-0
Pentafluorobenzonitrile

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

: 1346641-99-3
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,3-bis(cyclohexylmethyl)-1-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / water; ethyl acetate / 6 h / 20 °C

2: toluene / 12 h / Reflux

3: palladium diacetate; lithium carbonate; silver carbonate; p-benzoquinone / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

With ammonia; palladium diacetate; lithium carbonate; silver carbonate; p-benzoquinone; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja207607s