(alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide

Base Information

Chemical Name:(alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide
CAS No.:5364-23-8
Molecular Formula:C₁₇H₁₄N₂O₃
Molecular Weight:294.31
Hs Code.:
DSSTox Substance ID:DTXSID801156472

Synonyms:DTXSID801156472;(alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide;5364-23-8

Suppliers and Price of (alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:294.10044231
Heavy Atom Count:22
Complexity:447

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)NC1=CC=CC=C1)N2C(=O)C3=CC=CC=C3C2=O
Isomeric SMILES:C[C@@H](C(=O)NC1=CC=CC=C1)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of (alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide

There total 7 articles about (alphaS)-1,3-Dihydro-alpha-methyl-1,3-dioxo-N-phenyl-2H-isoindole-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 62-53-3
aniline

: 4192-28-3
Phth-L-Ala-OH

: 5364-23-8,53730-47-5,97833-07-3
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-phenylpropanamide

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 1h;
DOI:10.1021/ol048771l

Reference yield:

: 85-44-9
phthalic anhydride

: 5364-23-8,53730-47-5,97833-07-3
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂O / 0.5 h / microwave irradiation

2: 99 percent / N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -20 °C

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1021/ol048771l

Reference yield:

: 4192-28-3
Phth-L-Ala-OH

: 5364-23-8,53730-47-5,97833-07-3
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

1.2: 1 h / 20 °C

2.1: dichloromethane / 2 h / Reflux

With triethylamine; In dichloromethane;
DOI:10.1007/s00044-010-9492-1