N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide

Base Information

• Chemical Name: N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide
• CAS No.: 47128-43-8
• Molecular Formula: C₁₇H₂₃N₃O
• Molecular Weight: 285.389
• Mol file: 47128-43-8.mol

Synonyms:

Chemical Property of N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide

There total 6 articles about N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

bromopropionitrile (2417-90-5) + Norfentanyl (1609-66-1) → N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide (47128-43-8)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetonitrile;

DOI:10.1007/s00044-012-0390-6

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide (47128-43-8)

Guidance literature:

Multi-step reaction with 5 steps

1: zinc; acetic acid / water / 36 h / 20 - 70 °C

2: 1,2-dichloro-ethane / 20 °C

3: sodium hydroxide / water

4: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 50 °C

5: potassium carbonate; tetrabutylammomium bromide / acetonitrile

With palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; zinc; In methanol; water; acetic acid; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1007/s00044-012-0390-6

Reference yield:

1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) → N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide (47128-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,2-dichloro-ethane / 20 °C

2: sodium hydroxide / water

3: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 50 °C

4: potassium carbonate; tetrabutylammomium bromide / acetonitrile

With palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; potassium carbonate; sodium hydroxide; In methanol; water; acetic acid; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1007/s00044-012-0390-6

upstream raw materials:

bromopropionitrile

Norfentanyl

1-phenylmethyl-4-piperidone

N-(1-Benzyl-4-piperidyl)-N-phenylpropanamide Hydrochloride