N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl

Base Information

• Chemical Name: N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
• CAS No.: 5156-58-1
• Molecular Formula: C₂₁H₂₆N₂O*ClH
• Molecular Weight: 358.911
• Mol file: 5156-58-1.mol

Synonyms:

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Chemical Property of N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl

There total 3 articles about N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propionyl chloride (79-03-8) + 1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) → N-(1-Benzyl-4-piperidyl)-N-phenylpropanamide Hydrochloride (5156-58-1)

Guidance literature:

In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1007/s00044-012-0390-6

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-(1-Benzyl-4-piperidyl)-N-phenylpropanamide Hydrochloride (5156-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; acetic acid / water / 36 h / 20 - 70 °C

2: 1,2-dichloro-ethane / 20 °C

With acetic acid; zinc; In water; 1,2-dichloro-ethane;

DOI:10.1007/s00044-012-0390-6

Reference yield:

aniline (62-53-3) → N-(1-Benzyl-4-piperidyl)-N-phenylpropanamide Hydrochloride (5156-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; acetic acid / water / 36 h / 20 - 70 °C

2: 1,2-dichloro-ethane / 20 °C

With acetic acid; zinc; In water; 1,2-dichloro-ethane;

DOI:10.1007/s00044-012-0390-6

upstream raw materials:

1-phenylmethyl-4-piperidone

aniline

propionyl chloride

1-benzyl-N-phenylpiperidin-4-amine

Downstream raw materials:

Norfentanyl

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide

N-(1-propyl-4-piperidinyl)propionanilide

N-(1-(2-phenoxyethyl)-4-piperidinyl)propionanilide