2-Hydroxy-6-methoxy-4-methylbenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-6-methoxy-4-methylbenzaldehyde
• CAS No.: 39503-23-6
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• NSC Number: 143586
• DSSTox Substance ID: DTXSID20301460
• Nikkaji Number: J1.174.285H
• Wikidata: Q82045409
• Mol file: 39503-23-6.mol

Synonyms:39503-23-6;2-hydroxy-6-methoxy-4-methylbenzaldehyde;NSC143586;SCHEMBL5358719;DTXSID20301460;NSC-143586

Chemical Property of 2-Hydroxy-6-methoxy-4-methylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00134mmHg at 25°C
• Boiling Point: 288.6°C at 760 mmHg
• Flash Point: 115.8°C
• Density: 1.188g/cm³
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)OC)C=O)O

Technology Process of 2-Hydroxy-6-methoxy-4-methylbenzaldehyde

There total 19 articles about 2-Hydroxy-6-methoxy-4-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acide formyl-3-hydroxy-2-methoxy-4-methyl-6-benzoique (15918-51-1) → hydroxy-2-methoxy-6-methyl-4-benzaldehyde (39503-23-6)

Guidance literature:

With [2,2]bipyridinyl; In diethylene glycol dimethyl ether; for 5h; Heating;

DOI:10.1002/hlca.19880710424

Reference yield: 80.0%

2,6-dimethoxy-4-methylbenzaldehyde (6937-96-8) → hydroxy-2-methoxy-6-methyl-4-benzaldehyde (39503-23-6)

Guidance literature:

With aluminium trichloride; sodium iodide; In dichloromethane; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/anie.200502913

Reference yield: 76.87%

2-methoxy-6-[(4-methoxyphenyl)methoxy]-4-methylbenzaldehyde → hydroxy-2-methoxy-6-methyl-4-benzaldehyde (39503-23-6)

Guidance literature:

2-methoxy-6-[(4-methoxyphenyl)methoxy]-4-methylbenzaldehyde; With sodium hydride; In dichloromethane; at 20 ℃; for 0.5h;

With trifluoroacetic acid; In dichloromethane; for 1h;

upstream raw materials:

chloroform

aniline hydroiodide

2,6-dimethoxy-4-methylbenzaldehyde

4-(3-formyl-2-hydroxy-4-methoxy-6-methylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoic acid

Downstream raw materials:

acide hydroxy-2-methoxy-6-methyl-4-benzoique

acide dichloro-3,5-hydroxy-2-methoxy-6-methyl-4-benzoique

2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate

methyl 3-(2-methoxy-4-methyl-6-(2-oxoethyl)phenyl)propiolate