2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

Chemical Name:2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
CAS No.:137023-09-7
Molecular Formula:C₃₆H₃₈N₂O₅
Molecular Weight:578.708
Hs Code.:

2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Chemical Property of 2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Technology Process of 2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 5 articles about 2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 137023-09-7
2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 5 steps

1: 53.7 percent / sodium acetate, acetic anhydride / 1) 125 deg C, 4 h, 2) rt, overnight

2: 90.1 percent / H₂ / palladium black / acetic acid / 12 h / 60 °C

3: 68.2 percent / NaH / dimethylformamide / 1) 60 deg C, 30 min, 2) rt, 4 h

4: LiAlH₂(OEt)2 / tetrahydrofuran / 0.25 h / -10 °C

5: CF₃CO₂H / Heating

With hydrogen; sodium acetate; acetic anhydride; sodium hydride; lithium diethoxyaluminum hydride; trifluoroacetic acid; palladium; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-17-7
(3Z,6Z)-3,6-Bis-(3,4-dimethoxyphenyl)methylenepiperazinedione

: 137023-09-7
2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 4 steps

1: 90.1 percent / H₂ / palladium black / acetic acid / 12 h / 60 °C

2: 68.2 percent / NaH / dimethylformamide / 1) 60 deg C, 30 min, 2) rt, 4 h

3: LiAlH₂(OEt)2 / tetrahydrofuran / 0.25 h / -10 °C

4: CF₃CO₂H / Heating

With hydrogen; sodium hydride; lithium diethoxyaluminum hydride; trifluoroacetic acid; palladium; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-19-9
1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

: 137023-09-7
2-(3,4-Dimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-8,9-dimethoxy-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₂(OEt)2 / tetrahydrofuran / 0.25 h / -10 °C

2: CF₃CO₂H / Heating

With lithium diethoxyaluminum hydride; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86518-2