1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

Base Information

Chemical Name:1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione
CAS No.:137023-19-9
Molecular Formula:C₃₆H₃₈N₂O₆
Molecular Weight:594.708
Hs Code.:

Synonyms:1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

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Chemical Property of 1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

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Technology Process of 1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

There total 3 articles about 1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

: 100-39-0
benzyl bromide

: 137023-18-8,137043-34-6
3,6-Bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

: 137023-19-9
1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1) 60 deg C, 30 min, 2) rt, 4 h;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 137023-19-9
1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 53.7 percent / sodium acetate, acetic anhydride / 1) 125 deg C, 4 h, 2) rt, overnight

2: 90.1 percent / H₂ / palladium black / acetic acid / 12 h / 60 °C

3: 68.2 percent / NaH / dimethylformamide / 1) 60 deg C, 30 min, 2) rt, 4 h

With hydrogen; sodium acetate; acetic anhydride; sodium hydride; palladium; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-17-7
(3Z,6Z)-3,6-Bis-(3,4-dimethoxyphenyl)methylenepiperazinedione

: 137023-19-9
1,4-Bis-(phenyl)methyl-3,6-bis-(3,4-dimethoxyphenyl)methyl-(3α,6α)-piperazinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 90.1 percent / H₂ / palladium black / acetic acid / 12 h / 60 °C

2: 68.2 percent / NaH / dimethylformamide / 1) 60 deg C, 30 min, 2) rt, 4 h

With hydrogen; sodium hydride; palladium; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86518-2