BUBU

Base Information

Chemical Name:BUBU
CAS No.:114414-60-7
Molecular Formula:C₄₁H₆₂N₆O₁₀
Molecular Weight:798.977
Hs Code.:
Mol file:114414-60-7.mol

Synonyms:L-Threonine,O-(1,1-dimethylethyl)-N-[N-[N-[N-[O-(1,1-dimethylethyl)-N-L-tyrosyl-D-seryl]glycyl]-L-phenylalanyl]-L-leucyl]-;BUBU

Suppliers and Price of BUBU

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of BUBU

Chemical Property:

Boiling Point:1096.2±65.0 °C(Predicted)
PKA:3.06±0.10(Predicted)
PSA：247.51000
Density:1.191±0.06 g/cm3(Predicted)
LogP:4.36430

Purity/Quality:: 96% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BUBU

There total 13 articles about BUBU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114442-56-7
N-(benzyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-t-butyl-L-threonine

: 114414-60-7
Tyr-D-Ser(O-t-Bu)-Gly-Phe-Leu-Thr(O-t-Bu)

Guidance literature:: With hydrogen; trimethyleneglycol; In methanol; for 3h; Ambient temperature;
DOI:10.1021/jm00118a005

Reference yield:

: 4313-73-9
N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-L-leucine

: 114414-60-7
Tyr-D-Ser(O-t-Bu)-Gly-Phe-Leu-Thr(O-t-Bu)

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / 1-hydroxybenzotriazole, DCC / tetrahydrofuran; CHCl₃; triethylamine / 0 deg C, 1h; RT, overnight

2: 1 N NaOH / methanol / 0 deg C, 1 h; RT, 16 h

3: 95 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

4: 1.) OHNSu, DCC, 2.) 1-hydroxybenzotriazole, DCC / 1.) DMF, -20 deg C, 0.5 h; 0 deg C, 1 h, RT, overnight, 2.) DMF, 0 deg C

5: 95 percent / H₂ / PdO / methanol / 3 h / Ambient temperature

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; trimethyleneglycol; In tetrahydrofuran; methanol; chloroform; triethylamine;
DOI:10.1021/jm00118a005

Reference yield:

: 1164-16-5
Z-L-Tyr-OH

: 114414-60-7
Tyr-D-Ser(O-t-Bu)-Gly-Phe-Leu-Thr(O-t-Bu)

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Et₃N, HOBT, DCC / tetrahydrofuran; CHCl₃

2: 97 percent / 1 N NaOH / methanol / 0 deg C, 1 h; RT, 6 h

3: 67 percent / Et₃N, DCC / tetrahydrofuran; CHCl₃ / 0 deg C, 1h; RT, overnight

4: 72 percent / 1 N NaOH / methanol / 0 deg C, 1h; RT, 5 h

5: 1.) OHNSu, DCC, 2.) 1-hydroxybenzotriazole, DCC / 1.) DMF, -20 deg C, 0.5 h; 0 deg C, 1 h, RT, overnight, 2.) DMF, 0 deg C

6: 95 percent / H₂ / PdO / methanol / 3 h / Ambient temperature

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trimethyleneglycol; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00118a005